Welcome to the Hardiman Lab at UCSD, Department of Medicine

Biogem/Hardiman Lab

If you are looking for the Biomedical Genomics Facility (BIOGEM) please click here

Who are we?

The Hardiman lab consists of Gary Hardiman (Principal Investigator), Colleen Ludka (Staff Research Associate), James Sprague (Staff Research Associate), Cataldo Ribecco (Visiting Graduate Student), Andrea Martella (Visiting Graduate Student) and Narimene Lekmine (Programmer Analyst). For more information on lab members past and present please check out our People page.

What we do?

The Hardiman lab has several ongoing research projects, which include:

  • Endocrine disruptors

    We are employing molecular methods to identify biomarkers for several chemicals of emerging concern. These chemicals interfere with diverse physiological pathways in humans.

  • Cystic Fibrosis gene modifiers

    Cystic fibrosis is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, but there is great heterogeneity of lung-disease severity. We are investigating non-CFTR genetic factors (modifier genes) that contribute to the severity of CF.

  • Microarray based diagnostic assays

    To be useful in clinics, a diagnostic test must be easy to implement and to conduct in a standard clinical setting. Three important qualities of molecular diagnostic testing are sensitivity, specificity, and ubiquity. We are employing microarray based approaches to develop integrated diagnostic assays.

  • Optimization of protein array fabrication

    The microarray format is well suited for measuring biomarkers since it is a sensitive multiplex assay that requires small amounts of material. We are developing reverse phase arrays by spotting cell lysates or antigen targets on the surface of slides and probing with specific antibodies.

  • Salmon Smoltification

    Saltwater meets freshwater in coastal estuaries, generating "brackish" water. When salmon fry enter estuaries, they begin to adapt to saltwater, a process called "smoltification." Salmon alter their metabolism in preparation for movement from freshwater to seawater. This process is a spectrum of morphological, biochemical and behavioral changes that transform the juvenile parr living in freshwater into the smolts that live in seawater. All body tissues are involved in the process, with a dominant role being played by the gills. Other tissues of importance are the liver and kidney.

For more information please visit our Research page

Several collaborative genomics projects are ongoing with investigators at UCSD, UCR and The University of Camerino (Italy)

Where are we located?

The Hardiman lab can be contacted at the following address:

The Leichtag Family Foundation Biomedical Research Building, Room 172
9500 Gilman Drive
La Jolla CA 92093-0724
Tel: 858-822-3792
Fax: 858-822-6430
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

If you are looking for the Biomedical Genomics Facility (BIOGEM) please click here